Treatment of skin burns with stem cells Click To Tweet They also cause severe pain and discomfort to the patient himself.
Burns can be not only extensive, but also very deep, touching and interfering with the work of internal organs.
Burns are classified by: the affected area; origin (radiation, alkalis, acids, fire, electric current); depth (damage with alkalis, for example, leads to very deep scabs, which often need to be excised); the nature of the injury. Click To Tweet
Burn treatment depends on all of these factors. In general, it consists in excising necrotic tissues (if necessary), restraining the growth of microflora, stimulating healing processes and, if necessary, xeno- or autoplasty (covering the damaged area of the skin with the skin of a patient or animal). In this case, an extensive scar may remain on the skin, which is then removed with the help of plastic surgery and milder therapeutic methods. Therapy, including regenerative therapy using cellular material, consists in stimulating the growth of connective tissue and forming the most elastic scar, as well as preventing the development of complications, as well as infection of the affected area. The duration of treatment after burns varies and can range from a few days to several months.
Treatment of burns with fibro blasts
In the regenerative therapy of burns, to date, two types of biological material have shown the greatest efficiency due to their special properties: MSCs and fibroblasts (mature skin cells). Any of these materials can be successfully applied to a designated group of patients.
Fibroblasts act as a regulator and synthesizer of extracellular matrix elements and cell migration. The extracellular matrix is the structures that support the cell’s viability and direct its movement. It is by signals from the extracellular matrix that cells migrate to the affected area.
In the treatment of burns with fibroblasts / MSCs, surgical autoplasty is not required, although a combined regimen of management of burn patients can also be used. The body receives additional support and building material for connective tissue and quickly begins the recovery process. Fibroblasts can be obtained from the skin of a patient or donor.
Stages of treatment for burns
1st Stage: Preliminary consultation with a doctor, taking tests, prescribing therapy and treatment
2 stage : Collection of fibroblasts from the patient’s body or preparation of donor material
3 stage : Cultivation of fibroblasts in the laboratory and establishment of a colony
4 stage : Application of prepared biomaterial using non-invasive methods for topical application